![]() In-patient diabetes insulin therapy pregnancy. Further study of women with type 2 diabetes is required. The Pregnancy-IVI algorithm is safe and effective when used following betamethasone in type 1 diabetes in pregnancy. The Pregnancy-IVI was most effective in women with Type 1 diabetes. ![]() No difference in the rate of neonatal hypoglycaemia was observed. Glycaemic variability was significantly reduced with Pregnancy-IVI. The duration of critical hyperglycaemia with Pregnancy-IVI was also reduced (2% vs 8%, p < 0.0001), without an increase in hypoglycaemia. Overall, Pregnancy-IVI achieved a higher proportion of on-IVI time-in-range (70%, IQR 56-78%) compared to Adult-IVI (52%, IQR 41-69%, p < 0.0001). Analysis was stratified by diabetes type. Secondary outcomes included time with critical hyperglycaemia (BGL > 10 mmol/L) occurrence of maternal hypoglycaemia (BGL < 3.8 mmol/l) and incidence of neonatal hypoglycaemia (BGL ≤ 2.5 mmol/L). ![]() The primary outcome was on-IVI glycaemic time-in-range (capillary blood glucose (BGL) 3.8-7.0 mmol/L). We hypothesised that Pregnancy-IVI would be superior to a generic Adult-IVI protocol (prior standard of care) following betamethasone in women with pre-existing diabetes.Ī retrospective cohort study enrolled all women with pre-existing diabetes at a tertiary centre receiving betamethasone and treated with IVI according to one of two protocols: Adult-IVI (n = 73, 2014-2017) or Pregnancy-IVI (n = 62, 2017-2020). The Pregnancy-IVI, an intravenous-insulin (IVI) algorithm, has been validated in gestational diabetes however, its performance in pre-existing diabetes (Type 1 and Type 2 diabetes) is not known. ![]() At our fertility clinics in Madrid, Valencia, Barcelona, Mlaga, Bilbao, Saint Sebastian, Las Palmas, Seville, Mallorca and Alicante, we have medical. Hyperglycaemia following antenatal corticosteroids is common in women with diabetes in pregnancy, and validated algorithms to maintain pregnancy-specific glucose targets are lacking. IVI, is a leading reproduction medicine centre, offering the best fertility treatments and techniques in Spain, both to Spaniards as to foreign patients. ![]()
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